Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients
نویسندگان
چکیده مقاله:
Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population. Methods: Fifty patients with Bullous pemphigoid and 180 geographically matched, healthy individuals as control group enrolled into this study. HLA typing of class II (DR and DQ alleles) was carried out using polymerase chain reaction based on sequence-specific primers method. Results: Class II DQA1 and DQB1 typing showed a significantly higher frequency of HLA-DQA1*05:01 (45% vs. 33%, p=0.03), HLA-DQB1*03:01 (36% vs. 23.6%, p=0.02) and HLA-DQB1*04:01 (4% vs. 1.6%, p=0.04) in the BP patients compared with controls. For DRB1 allele frequencies, there were no significant disease associations. The frequency of DRB1*08:01/DQA1*05:01/DQB1*03:01 (3% vs. 0%, p=0.02) haplotype showed an increase among patients compared with controls. Conclusion: Our data suggest that Iranian patients with BP present the same genetic predisposition linked to HLA-DQB1*03:01 previously reported in Caucasians.
منابع مشابه
Association between HLA-DQB1*03:01 and Bullous pemphigoid in Iranian patients.
BACKGROUND A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. OBJECTIVE To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population. METHODS Fifty p...
متن کاملassociation between hla-dqb1*03:01 and bullous pemphigoid in iranian patients
background: a common human leukocyte antigen (hla) class ii allele, dqβ1*03:01, seems to be associated with bullous pemphigoid (bp) in caucasians whereas previous studies in other ethnic groups showed other hla class ii alleles as genetic predisposing factors for bp. objective: to investigate the association of hla class ii alleles and haplotypes with bp in iranian population. methods: fifty pa...
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Methods | Our study cohort comprised all newly diagnosed patients with BP who were seen at the National Skin Centre in Singapore from April 1, 2004, to December 31, 2009. A diagnosis of BP was based on the presence of at least 3 of 4 criteria: (1) clinical findings consistent with BP; (2) histopathological findings of subepidermal blister; (3) a direct immunofluorescence finding of IgG and/or c...
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عنوان ژورنال
دوره 10 شماره 1
صفحات 1- 9
تاریخ انتشار 2013-03-01
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